Simultaneous Determination of Norepinephrine, Acetaminophene and Folic acid by a Novel Electrochemical Sensor Based on TiO2 Nanoparticles

A carbon paste electrode modified by 2,2_-[1,2 buthanediylbis(nitriloethylidyne)]-bis-hydroquinone (BNH) and TiO2 nanoparticles prepared by a simple and rapid method. This modified electrode showed an excellent character for electrocatalytic oxidization of norepinephrine (NE). The results showed an efficient catalytic activity of the electrode for the electrooxida+on of NE, which leads to a reduc+on in its overpoten+al by more than 270 mV. The modified electrode exhibits an efficient electron-mediating behavior together with well-separated oxidation peaks for NE, acetaminophene (AC) and folic acid (FA). Differential pulse voltammetry (DPV) peak currents of NE, AC and FA increased linearly with their concentra+on at the ranges of 4.0–1100.0 μM, 12.5–500.0 μM and 200.0–3200.0 μM, respectively and the detec+on limits for NE, AC and FA were 0.5 μM, 2.6 μM and 25.0 μM, respec+vely.