Plasma Micro-RNA and depression,diognosis and treatment

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 336

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شناسه ملی سند علمی:

NSCMED08_098

تاریخ نمایه سازی: 15 دی 1398

چکیده مقاله:

Background and Aim : Major depression is common psychiatric disorder. The diagnosis of depression is an important subject and depends on subjective complaints, and the quality of the heterogeneous disorder. Recently some biomarkers have been diagnosed which can determine the early diagnosis and progress of treatments of depression patients .Previous research has shown that microRNAs are dysregulated in bipolar disorder and schizophrenia .this review discuss about micro-RNAs which involve in depression.Methods : For this aim we have searched through journals DATA bases and PubMed,Elseviers,Web of Sciences and google scholars sites by considering more than 40 articles which discussed around this option and reached to nice results.Results : The most important findings were documents about down-regulation of miR-320a and the up-regulation of miR-451a.Two studies have shown the importance ofmiR-320 family as a plasma marker in autism and major depression. Also 8 microRNAs were down-regulated in plasma of autism patients, including miR-320a . Also MiR-101-3p, miR-106-5p, miR-423-5p, and miR-93-5p upregulated in the plasma of depressed patients .Also it was found that these two statistically Significant microRNAs were related to genes: GRIN2A, DISC1, and SLC17A7 .GRIN2A, and DISC1 have been shown to be predicted targets for miR-320a (mirdb.org). Aslo it was demonstrated that glutamatergic genes -including GRIN2A-were unregulated in individuals who experienced suicide during a depressive period. Besides, mice studies revealed that knock-out of GRIN2A indicates an antidepressant response-like behavior . Recent data also suggest that GRIN2A up-regulation is related to depression, and the knock-out of GRIN2A is related to an antidepressant response-like behavior.Conclusion : MiR-320a is down regulation and miR-451a is upregulation in major depression are in most consider. In particular, accumulating data provide evidence that the miR-320 family is dysregulated in major depression. In addition, miR-451a could serve as a candidate biomarker for depression based on the acting mechanism of ketamine. Studies targeting miR-451a levels before and after treatment could be helpful .Also genes: GRIN2A, DISC1, and SLC17A7 have been shown to be related with miR-320a .In future role of micro-RNA as diagnostic and progressive markers would be in major consider of Depression control and curing managements.

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نویسندگان

Ramin Ataee

Pharmaceutical Sciences Research Center,Hemoglobinopathy institute,Mazandaran University of Medical Sciences ,Sari Iran

Amin Ataee

Department of Pharmacology,Babol University of Medical Sciences,Babol Iran

Moien Khoshsaz

Pharmaceutical Sciences Research Center,Hemoglobinopathy institute,Mazandaran University of Medical Sciences ,Sari Iran