Dendrimer Modified Magnetic Nanoparticles as a Promising Platform for Cancer Theranostics

Background and Aim: Over the past decades, increasing interests havebeen devoted to the synthesis of functionalized magnetic nanoparticles(MNPs) due to their biocompatibility, biological degradability, targetingability, and remarkable magnetic properties. Nanoparticles have highsurface energy, so tend to agglomerate resulting in a loss of magnetismand dispersibility. To overcome this obstacle, it is necessary to protectnanoparticles by polymers or other agents such as dendrimers, takinginto account their biocompatibility, to chemically stabilize the magneticnanoparticles against aggregation.Methods: In this study, a precipitation method had been used for thesynthesis of iron oxide nanoparticles. At first, the MNPs had beenmodified with (3-aminopropyl) triethoxysilane, and then PAMAMfunctionalized MNPs had been synthesized cycling. These MNPs hadbeen characterized by SEM, TEM, XRD, and VSM. The toxicity of theseMNPs had been evaluated by MTT. Thereafter their inductive heatproperty by an ac magnetic field generator and the MRI properties wereinvestigated.Results: In this paper, various characterization techniques were used toinvestigate the properties of the synthesized nanocomposites. Cytotoxicityassay confirmed the biocompatibility of the nanocomposites. A superiorheat generation was achieved for the given concentration accordingto the hyperthermia results. MRI results show that the synthesizednanocomposites are a favorable option for MRI contrast agent.Conclusion: We believe that these dendrimer functionalized MNPs havethe potential of integrating therapeutic and diagnostic functions in asingle carrier.

کلیدواژه ها:

Magnetic nanoparticles ، Dendrimer ، Hyperthermia ، Magnetic resonance imaging