Microfluidic Preparation Routes for Organic Nanoparticles and Vesicular Systems for Nanomedicine Applications

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 315

نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

NSCMRMED03_317

تاریخ نمایه سازی: 30 دی 1397

چکیده مقاله:

Background and Aim: Microfluidic systems, with their capability forprecise handling and transport of small liquid quantities, have emerged asa promising platform for designing advanced drug delivery systems. Wereport the development of a microfluidic-based process for the productionof polymeric micelles in continuous-flow microreactors where Pluronictri-block copolymer is used as model polymeric biomaterial relatingto drug delivery applications. We investigate the effect of polymerconcentration, flow rate ratio and the microreactor dimension on thePMs size characteristic and drug encapsulation efficiency.Methods: In this study, We developed a T-shape microfluidic device tocreate hydrodynamically focused flow consists of three inlets, one forthe polymeric solution, two for deionized water, and one outlet for thefabricated nanoparticles. Microfluidic devices were fabricated withpoly(dimethylsiloxane) (PDMS) using a standard soft lithography process.To make the master molds, silicon wafers were spin-coated with SU-82050 photocurable epoxy to a thickness of 60 μm. The mixing channelwas 150 μm wide, 60 μm high and 1 cm long.Results: Pluronic nanoparticle morphology trends found throughdynamic light scattering analysis were confirmed with Transmissionelectron microscopy (TEM). DLS measurement revealed that synthesizednanoparticles had the size between 250-400 nanometers.Conclusion: The diameter of the nanoparticles increases with an increasein flow ratio and polymer concentration. Moreover, the polydispersityindex (PI) for the microfluidic nanoparticles was found to be remarkablylower (PI<0.2) than bulk synthesized particles (PI > 0.6) which is animportant factor for drug delivery systems.

نویسندگان

Mojtaba Farahani

Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran

Amirhossein Rasouli

Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran

Iman Shabani

Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran