The Effect of Gelatin/Silica Hybrid Particle Size on Hemostatic Properties as a Styptic for Severe Bleeding

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 676

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شناسه ملی سند علمی:

NTNM01_010

تاریخ نمایه سازی: 7 اسفند 1396

چکیده مقاله:

Trauma and its results such as uncontrolled bleeding are some of the most common cause of death. The bleeding and its shock can be cause of serious injuries in vital organs like brain, heart and kidneys in the early stage. Therefore, fast hemostasis is essential as a strategy. The aim of this study was to investigate the effect of gelatin/silica hybrid particle size on hemostatic properties and especially on accelerating the coagulation cascade as a styptic for severe bleeding. The characteristics of blood coagulation (using activated partial thromboplastin time), platelet adhesion (loctate-dehydrogenase), blood and water absorption, structural properties (using UV visible spectroscopy) as well as size analysis (using dynamic light scattering) have been investigated. Hybrid hemostatic behavior varied drastically by changing the particle size, so that the hybrid with average particle size of about 1010nm demonstrated very poor ability in platelet adhesion with approximately 3% absorption. Also the activated partial thromboplastin time was just 2 seconds shorter than the normal time, whereas reduction of particle size beyond a certain limit (100nm), led to both increasing platelet adhesion rate to about 28% and very considerable reduction of PTT. In addition, the time of clot formation reduced by 30 seconds in activated partial thromboplastin time test. Alignment of all results showed that particle size reduction improves the hemostatic behavior of the gelatin/ silica hybrid toward its ideal performance by controlling excessive bleeding.

نویسندگان

m chenani

Biomaterials Group, Department of Medical Engineering, Science and Research Branch, Islamic Azad university,Tehran, Iran

a behnamghader

Biomaterials Group, Department of Nanotechnology and Advanced Materials, Materials & Energy Research Center, Karaj, Iran

m khorasani

Department of Biomaterial, Iran Polymer and Petrochemical Institute (IPPI), P.O. Box: ۱۴۹۶۵, Tehran, Iran

m Ahmadinejad

Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran,Iran