Association assessment of the Sesn2 gene polymorphisms rs7526084 and rs502273 with the risk of preeclampsia in women of south of Iran

Preeclampsia is one of the most prevalent disorders in pregnancy and considered as a systemic disease. Feto-maternal immune incompatibility, oxidative stress, genetic variants and endothelial cells injuries play an important role in the pathogenesis of the disease. The Sesn2 gene is responsible for coding the Sestrin-2 protein in humans. This gene is a member of the Sestrin gene family. The protein encoded by this gene plays a role in regulating cell growth and survival. The timely expression of the Sesn2 gene significantly reduces the level of ROS and increases the life span of the cell, while suppressing Sesn2 has increased ROS, which decreases the life span of the cell against H2O2. This study aimed to investigate the relationship between rs502273 and rs75260840 polymorphisms of Senes2 gene and the incidence of preeclampsia in women of south of Iran.