Antibiotic-Resistance Determinants in Acinetobacter Baumannii Strains Isolated from Foot Diabetic Infection in Isfahan-Iran

Background: Acinetobacter baumannii is an important multidrug-resistant opportunistic pathogen that frequently causing various nosocomial infections and is a serious threat to burn patients. These infections usually caused by the outbreak strains. The aim of this study was to show antibiotic resistance pattern and molecular typing of A.baumannii genes isolates collected from foot diabetic patients. Material and Methods: In this study, 307 different strains was detected. 100 Acinetobacter baumannii strain was selected in Isfahan hospitals. Antibiotic resistance pattern was determined by disk diffusion method (Kirby Bauer). The presence of genes coding in antibiotic resistance were analyzed by using of M-PCR method. Results: The antibiotic resistance pattern for Acinetobacter baumannii show the high resistance for ciprofloxacin, ceftazidime, and tetracycline with frequency of 97.2%, 88.3%, and 86.2%, respectively. Moreover, the most sensitive antibiotics were chloramphenicol, and nitrofurantoin with frequency of 3.9% and 2.8% resistance. CITM (91.1%) was the highest detected genes. Conclusion: High prevalence of antibiotic resistance pattern among Acinetobacter baumannii isolated from foot diabetic patients in Isfahan hospitals indicate he importance role of multidrug resistant isolates.

کلیدواژه ها:

Acinetobacter Baumannii ، Multidrug-Resistant ، Burn Patient ، M-PCR