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گواهی نمایه سازی مقاله 1,3-Dibromo-5,5-dimethylhydantoin: a versatile catalyst for synthesis of 3,3-bis(indolyl)oxindoles

عنوان مقاله: 1,3-Dibromo-5,5-dimethylhydantoin: a versatile catalyst for synthesis of 3,3-bis(indolyl)oxindoles
شناسه (COI) مقاله: JR_ICC-1-1_006
منتشر شده در فصلنامه ارتباطات شیمی ایران در سال ۱۳۹۲
مشخصات نویسندگان مقاله:

Seyyedeh Fatemeh Hojati - Department of Chemistry, School of Science, Hakim Sabzevari University, Sabzevar, 9617976487, Iran
Kobra Nikoofar - Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran, 1993891176, Iran
Zahra Etemadifar - Department of Chemistry, School of Science, Hakim Sabzevari University, Sabzevar, 9617976487, Iran

خلاصه مقاله:
A condensation of various isatins with indole derivatives has been carried out in the presence of 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) as catalyst at 50 °C in ethanol in order to form3,3-bis(indolyl) oxindoles. The products were obtained within 20-90 min by 70-96% yields. The efficacy of the procedure has been confirmed by catalyzing the condensation reaction of pyrrolewhich was used as another sort of heterocycle with indole to obtain its corresponding 3,3-bis(2-pyrrolyl)oxinole. A plausible mechanism of the condensation based on DBDMH activating rolehas also been proposed. DBDMH is an effective, commercially available, insensitive to moisture and easily handling catalyst. Simple procedure, easy work-up, mild reaction conditions, highyields and short reaction times are the highlighted points of reported method.

کلمات کلیدی:
1,3-Dibromo-5,5-dimethylhydantoin, isatin, indole, 3,3-bis(indolyl)oxindoles.

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