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گواهی نمایه سازی مقاله One-pot and one-step novel N-methylation of 2,6-Diaminopyridine

عنوان مقاله: One-pot and one-step novel N-methylation of 2,6-Diaminopyridine
شناسه (COI) مقاله: JR_ICC-2-3_002
منتشر شده در فصلنامه ارتباطات شیمی ایران در سال ۱۳۹۳
مشخصات نویسندگان مقاله:

Mehdi Nabati - Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran
Mehrdad Mahkam - Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran

خلاصه مقاله:
2,6-Diaminopyridine is extensively used as a pharmaceutical intermediate and a hair dye coupler. It is soluble in protic solvents. Primary and secondary amines are N-methylated by various methods such as direct alkylation of amines with Hofmann mechanism, but in many of these methods due to over-alkylations, we earn a mixture of amino products. Consequently, they aren't selective in the case of secondary amines preparation. Also, the synthesis of secondary amines is a problematic field in organic chemistry. In this research, 2,6-diaminopyridine N-methylatedselictivity was done from reaction with sodium azide and orthoformic ester in low time with good yields.

کلمات کلیدی:
2,6-Diaminopyridine, N-methylation, one-pot reaction, one-step reaction.

صفحه اختصاصی مقاله و دریافت فایل کامل: http://www.civilica.com/Paper-JR_ICC-2-3-JR_ICC-2-3_002.html