Zohreh Sarikhani - Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran
Razieh Nazari - Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran
Mahmoud Nateghi Rostami - Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran

Objective(s):Antibiotic resistance in Acinetobacter baumannii and outbreaks caused by this organism have been reported from several areas of the world. The present study aimed at determining the antibiotic susceptibility profiles and the distribution of OXA-type beta-lactamases among Iranian Acinetobacter baumannii isolates from Qom of Iran. Materials and Methods: For this study, ۱۰۸ non-duplicate A. baumannii isolates were obtained from clinical specimens in four teaching hospitals in Qom in the central of Iran. The antimicrobial susceptibility of isolates was tested by standard disk diffusion and prevalence of bla OXA genes was investigated by PCR method. Results: Among ۹۷ carbapenem non-susceptible isolates of A. baumannii, ۹۰.۷۲% (۸۸ isolates) isolates showed extensive drug resistance to multiple antibiotics. Among carbapenem resistant isolates, ۱۰۰% carried blaOXA-۵۱-like, ۸۲.۴۷% carried blaOXA-۲۳-like, ۵۵.۶۷% carried blaOXA-۵۸-like, ۲۲.۶۸% carried blaOXA-۴۰-like and ۱۴.۴۳% had blaOXA-۱۴۳-like resistance genes. Conclusion: This study demonstrated high genetic diversity of OXA genes among isolates of A. baumannii in Qom, Iran.

Acinetobacter baumannii, blaOXA-۱۴۳, Carbapenem resistance, Iran, Polymerase chain reaction