Soussan Irani - Associate Professor, Dental Research Centre, Oral Pathology Department, Dental Faculty, Hamadan University of Medical Sciences, Hamadan, Iran

Background: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer with high morbidity and mortality rates. Late diagnosis and high incidence rate of OSCC have become global healthcare issues. The purpose of this review was to provide an overview of the diagnostic and prognostic biomarkers in OSCC. Methods: A literature search in PubMed, ScienceDirect, and Google Scholar was performed. The keywords “early detection”, “oral cancer”, and “oral squamous cell carcinoma” were searched in the title and abstract of the articles published in English from ۲۰۰۰ to mid-۲۰۲۱. The full texts of ۲۵۰ articles were retrieved and only ۶۳ articles met the inclusion criteria. Results: In summary, all selected papers discussed the importance of early detection along with different factors and techniques to detect oral cancer. The biomarkers were divided into three groups as follows: salivary biomarkers, circulating biomarkers, and tissue biomarkers. Conclusions: In this review article, salivary biomarkers along with the circulating and tissue biomarkers were reviewed. Besides, some detection techniques were explained.

Mouth, Neoplasm, Precancerous