A.R Foromandi - assistant professor
P Haghighat
S Emami
M.H Moshefi - Assistant professor

Quinolone antibacterial agents are currently used for the treatment of various bacterial infections. The nature of functional group at the ۷ position of the quinolone ring system is known to have strong influence on the spectrum and extent of in vitro antibacterial activity. Accordingly, a series of N-L۲- oxo-۲-(۲- furyl) and N-[۲- oxyimino (۲- furyl) ethyl] piperazinyl quinolone derivatives were synthesized and evaluated for in vitro antibacterial activity. Compounds having ۲- oxo-۲-(-۲ furyl) ethyl group attached to the piperazine ring were as potent as norfloxacin and ciprofloxacin. The oximes were more active than corresponding ketones and original quinolone s against gram positive bacteria but less active against gram negative bacteria. The methyl oximes and O- benzyloximes were almost a potent as the corresponding quinolones against gram positive bacteria but less active against gram negative bacteria.

Synthesis, quinolones, Antibacterial Activity