Monitoring of atorvastatin in biological sample using supported liquid membrane-based microextraction combined with high performance liquid chromatography
عنوان مقاله: Monitoring of atorvastatin in biological sample using supported liquid membrane-based microextraction combined with high performance liquid chromatography
شناسه ملی مقاله: NCNC01_146
منتشر شده در اولین همایش ملی فناوری های نوین در شیمی و مهندسی شیمی در سال 1392
شناسه ملی مقاله: NCNC01_146
منتشر شده در اولین همایش ملی فناوری های نوین در شیمی و مهندسی شیمی در سال 1392
مشخصات نویسندگان مقاله:
Homayon Ahmad Panahi - Department of Chemistry, Islamic Azad University, Central Tehran Branch, Iran
Monireh Chabouk - Department of Chemistry, Islamic Azad University, Central Tehran Branch, Iran
خلاصه مقاله:
Homayon Ahmad Panahi - Department of Chemistry, Islamic Azad University, Central Tehran Branch, Iran
Monireh Chabouk - Department of Chemistry, Islamic Azad University, Central Tehran Branch, Iran
The use of hollow fiber membrane microextraction in analytical chemistry has been increasing as the technique is a simple and efficient method for the extraction of trace organic compounds fromenvironmental matrices. In this paper, a three phase hollow fiber-based liquid phase microextraction (HFLPME)combined with a HPLC procedure using UV-Vis detection has been developed for the determination of atorvastatin in biological sample. A Q3/2 Accurel PP polypropylene hollow fibersupporting 1-octanol was used between two aqueous solution (pH 4) as donor phase and (pH 11) asacceptor phase. Parameters such as extraction solvent, agitation of the sample, salt addition and extraction time were controlled and optimized. The proposed method was applied to the determination of the analyte in human urine and in environmental water and urine samples
کلمات کلیدی: Hollow fiber liquid phase microextraction, HPLC, Atorvastatin
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/211843/