m jalalifard - Department of Chemistry, Payame Noor University, PO BOX ۱۹۳۹۵-۳۶۹۷, Tehran, Iran
z hooshyar - Department of Chemistry, Payame Noor University, PO BOX ۱۹۳۹۵-۳۶۹۷, Tehran, Iran
g.r bardajee - Department of Chemistry, Payame Noor University, PO BOX ۱۹۳۹۵-۳۶۹۷, Tehran, Iran

A novel potentially biocompatible pH sensitive silver hydrogel nanocomposite based on poly (acrylic acid) grafted onto sodium alginate was synthesized for drug delivery of diclofenac sodium. To this aim, the potential of this hydrogel for diclofenac sodium release was examined. The results showed that 95% of diclofenac sodium was released in pH 8 after 4h at 37 ˚C which were best fitted with Korsmeyer kinetic model.

Diclofenac sodium, Drug delivery Nanocomposite, Silver