Farzaneh Fesahat - Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mehdi Khoshneviszadeh - Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Alireza Foroumadi - Department of Medicinal Chemistry, School of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
Alireza Vahidi - Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Some N-substituted piperidine structures were synthesized and evaluated for cytotoxicity. The N-substituted piperidine with propene substructurecould be considered as a lead structure for furtherstudies of structure activity relationship to develop more potent compounds in future. The compoundswere evaluated against four different cell lines using the standard MTT assay method and doxorubicin was used as the reference drug. The IC50 values weredetermined by constructing dose-response curves and revealed that three of the synthesized compounds were active against breast cancer cell lines. Compound 6a bearing hydroxyl at para position of piperidine ring was the most active compound within this series.

Piperidine, Cytotoxicity, Breast cancer