Javad Safaei-Ghomi - Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, ۵۱۱۶۷, I. R. Iran
Safura Zahedi - Young Researchers and Elite Club, Bandar abbas Branch, Islamic Azad University, Bandar abbas, Iran

Fe3O4-L-proline nanoparticles as a magnetic agent catalyzed the synthesis of isoxazolidines and spiroisoxazolidines via the one-pot three-component condensation reaction between N-arylhyroxylamine, arylaldehyde, isatines and α,β-unsaturated aldehyde under ultrasound irradiation. The application of ultrasonic irradiation improved the yields and reduced the reaction times. The use of Fe3O4-L-proline catalyst is feasible because of its easy preparation, easy handling, stability, easy recovery, reusability, good activity and eco-friendly.

isoxazolidines, sonochemical, L-proline, 1,3-dipolar cycloadditions