mohamad reza parhizkar - Alborz Bulk Pharmaceutical Co. ۵th St, Kaveh Industrial Zone, Saveh, I.R. Iran
s.vahid Shetab Boushehri - Department of Toxicology and Pharmacology, Faculty of Pharmacy & Nanotechnology Research Center, Medical Sciences/University of Tehran,
reza ghafoori - Pars Darion Co. Enghlab St, Saveh, I.R. Iran
maryam anafcheh - Department of Chemistry, Tarbiat Modares University, Tehran, I. R. Iran

After synthesis and manufacturing of drug, purification has a special place in pharmaceutical industries. For this purpose, common methods such as extraction, recrystallization, and column chromatography have been used for many years but some of them are expensive and not cost-effective. In present article, activated natural zeolite, clinoptilolite as an adsorptive solid phase for citalopram base and elimination of its impurities has been used for reaching over 99% purity in final product, citalopram hydrobromide. Citalopram hydrobromide is an antidepressant drug and selective serotonin reuptake inhibitor and its higher purity results in higher efficiency and lesser adverse drug reactions.

Citalopram, Purification, Recrystallization, Zeolite