Fahimeh Nourbakhsh - Ph.D Student of Toxicology, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, mashhad, Iran
Vajiheh Nourbakhsh - Ph.D Student of Toxicology, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, mashhad, Iran
Elaheh Tajbakhsh - Ph.D Student of Toxicology, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, mashhad, Iran
Samaneh Borooni - Ph.D Student of Toxicology, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, mashhad, Iran

Background: Staphylococcus aureus is one of the important pathogen all around the world. The present investigation carried out to study the distribution of SCCmec types and antibiotic resistance properties in methicillin-resistance Staphylococcus aureus isolated from Diabetic Foot Infections in 2017. Methods: 230 clinical wound specimens were collected from Isfahan wound center in Isfahan hospital. Samples cultured, and biochemical method used to confirm isolates. Methicillin resistance isolates subjected to several M-PCR methods. The patterns of antibiotic resistance were studied using disk diffusion method. Results: We found that 100 out of 200 samples detected from Diabetic Foot Infections and 90% of them were resistance to methicillin. The most commonly infected samples collected from woman’s (63%). Of mec positive strains, the distribution of SCCmec III (35%) was the highest type. Conclusions: This infection with these strains require more advanced hospital care with emerging demand for novel antibiotics and infections with these strains require higher levels of hospital cares with emerging demand for novel antibiotics. Hence, the clinicians’ role in judicious usage of antibiotics is pivotal.

Methicillin Resistance, Diabetic Foot Infections, SCCmec Typing, Staphylococcus