The Possible Role of Long Non coding RNA as Novel Player in Type 2 Diabetes
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 425
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شناسه ملی سند علمی:
CIGS15_079
تاریخ نمایه سازی: 13 بهمن 1398
چکیده مقاله:
Type 2 diabetes mellitus (T2DM) is a chronic disease with increasing rate of prevalence in the world that causes substantial public health and economic burden. Although more than 20 genetic susceptibility loci have been reported for type 2 diabetes (T2D), most reported variants have small to moderate effects and account for only a small proportion of the heritability of T2D, suggesting that the majority of inter-person genetic variation in this disease remains to be determined, So finding genetic variants plays an important role and provides a lot of data. Since non coding region is likely to have a significant effect on pathogenicity and susceptibility of diabetic and cardiovascular diseases, then it is useful to study the involved lncRNA.Materials and methods: Analysis of RNA-Seq data has revealed there are three lncRNAs ( PVT1, H19, CDKN2B-AS1) that are associated with diabetes. Among these lncRNAs, PVT1 was selected and assessment its functional and regulatory role was done by bioinformatics.Conclusion: PVT1 bioinformatics analysis has shown there is association between variants (rs2720709, A> G) in the plasmacytoma variant translocation 1 gene (PVT1) and end-stage renal disease (ESRD) attributed to both type 1 and type 2 diabetes and the SNP has key role in both pathogenicity and gene regulation. PVT1 fullfills its role by modulating the function of some transcription factors such as c-Myc, P53, YY1.
نویسندگان
Shabnam Javanzad
Department of Genetics, Faculty of Biological Sciences, Tarbait Modares University, Tehran, Iran
Zahra Abedi Kichi
Department of Genetics, Faculty of Biological Sciences, Tarbait Modares University, Tehran, Iran
Mehrdad Behmanesh
Department of Genetics, Faculty of Biological Sciences, Tarbait Modares University, Tehran, Iran