The relationship between ADIPOQ and ADIPOR2 gene polymorphisms with type 2 diabetes

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 345

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شناسه ملی سند علمی:

CIGS15_384

تاریخ نمایه سازی: 13 بهمن 1398

چکیده مقاله:

Today we are seeing an increase in the longevity and change in the lifestyle of people around the world.One of them is the transformation of the disease pattern and the prevalence of chronic diseases,including diabetes specially Type2 diabetes(the most common type of diabetes. Adiponectin, one of the adipokines has recently attracted the attention of many researchers,especially for studies of determining the relevance of genetic susceptibility to type 2 diabetes. Adiponectin is encoded by the ADIPOQ gene. Adiponectin acts by binding to its receptors (AdipoR1 and AdipoR2) and has the potential to lower the risk of type 2 diabetes. ADIPOQ and ADIPOR2 SNPs have been reported in many populations. Methods:A total of 180 participants, including 90, T2DM patients and 90 healthy control subjects (normal glucose tolerant (NGT). We collected clinical data , Serum insulin concentration ( estimated using an enzyme-linked immunosorbent assay)and Total serum adiponectin (measured by radioimmunoassay).we only selected two SNPs (rs1501299, and rs7627128 that are all tagSNPs of the ADIPOQ gene, which can represent the genetic information of the other SNPs in the ADIPOQ gene. Results:For total participants, the genotype and the allele frequency of rs1501299 and rs7627128 were significantly different between the T2DM patients and the control subjects. In the present study,we found that the ADIPOQ gene rs1501299 and rs7627128 polymorphisms were significantly associated with T2DM in population.conclusion :In conclusion, the present results indicate that T2DM is associated with the ADIPOQ gene polymorphisms.

کلیدواژه ها:

ADIPOQ - ADIPOR2 - gene polymorphisms -type2 diabetes

نویسندگان

Sahar Moazenrad

Research Deputy, Golestan University Of Medical Sciences,Gorgan, Iran.

Hanzaleh Balakheyli

Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Pardis Cheraghali

Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran.