Risk of thyroid cancer in women with infertility

Introduction: The increasing use of assisted reproductive methods and, consequently, thesignificant increase in the use of Fertility Drugs has doubled the concerns about infertilityrelevance and the risk of malignancy for both providers and patients. Information on therelationship between infertility and non-gynecological cancers including thyroid cancer isinconsistent. The present study is a review of the evidence regarding the risk of thyroidcancer in women with infertility.Method :Methods: This study was a review of a number of articles on thyroid cancer inwomen with infertility using keywords: infertility, ovulation, fertility drugs, thyroid cancer,women, through searches on the PubMed database, Magi ran ,CINAHL, Medline, Googlescholar, Scopus, ISI, over a 19-year period (2019-2000) and finally about 20 related articleswere collected .Results: Studies on the relationship between thyroid cancer risk and infertility treatment areinconsistent. Most studies show a positive association between infertility treatment andthyroid cancer risk. These included 2 meta-analyzes and 8 cohort studies and 3 reviewstudies. A meta-analysis( 2008)also reported that infertility treatment increased the risk ofthyroid cancer by approximately %35.Large cohort studies in Taiwan (2019), Denmark with38year follow-up (2008), China (2018) and America (2019) and systematic review (2018)have reported a positive relationship between thyroid cancer risk and the use ofunproductive drugs. Estrogenic drugs are probably mediated by the mitotic activity offollicular cells in the thyroid gland and indirectly by the increase in thyroid hormonebindingglobulin, are linked to thyroid cancer.But studies have rejected the association, the most important is a systematic review ofcancer risk assessment after assisted reproductive procedures, which have reviewed 95articles and announced that reproductive treatments have not increased the risk of cancer inbreast, cervical, endometrium, ovary, melanoma, colon and thyroid.Conclusion: The relationship between infertility and thyroid cancer is very complex and large-scale prospective studies and long-term follow-up are needed to evaluate the progression of thyroid cancer in infertile women.

کلیدواژه ها:

Infertility ، Ovulation ، Fertility Drugs ، Thyroid Cancer ، Women