Toward an Optimum Treatment of Thyroid Disorders: Personalized Thyroid Hormone Set-Points for Patients

Introduction: Clinicians recognize patients persistently experience residual symptoms of thyrotoxicosis or hypothyroidism etc. despite having achieved circulating levels of TSH and FT4 within the conventional normal ranges. In fact, many pathological conditions affect preferred TSH and FT4.Materials & Methods: A comprehensive literature search was performed on PubMed, UPTODATE and NCBI over publications within the last 3 decades. A total number of 43 references were retrieved based on search terms including thyroid hormone reference intervals, age; sex; and related TSH intervals, thyroid disorders and optimal TSH range. We extracted data about concentration of thyroid hormones in various pathological conditions. A GUI was then developed based collected data matrix to calculate individualized thyroid hormone set points based on patient input parameters comprise age, sex and several routine pathological conditions e.g. hypothyroidism, total thyroidectomy.Results: Both euthyroid set points of patients with primary hypothyroidism, total thyroidectomy, and lobectomy etc., can be straightforwardly derived from hormone calculator App using personal indications of each patient. It can be shown that every individual has a preferred personalized set point.Conclusion: This software provide the preferred set points to be rationally computed using our proposed algorithm implementable for computer-aided calculations. This could facilitate precise targeted dosing of patients in personalized medicine.