Comparison of Pregnancy Outcomes in High Risk Pregnant Women with Normal FBS after OGTT Test in First Trimester of Pregnancy and 24-28 Weeks of Pregnancy

Introduction: Diabetes mellitus is one of the most common metabolic disorders that may lead to pregnancy with serious complications. The aim of this study is Comparison of pregnancy outcomes in high risk pregnant women with normal FBS after OGTT test in first trimester of pregnancy and 24-28 weeks of pregnancy Materials & Methods: This was a follow up study on 415 pregnant mothers who were at risk of developing gestational diabetes mellitus (GDM) at the beginning of the first trimester of pregnancy. Patients were divided to 2 gropus: 164 women had a 2-hour OGTT test with 75 g glucose in the first trimester and 251 ones had 2-hour OGTT test with 75 g glucose in the second trimester. The studied population were monitored during the entire pregnancy period in term of complications of GDM. Results: Based on results, the prevalence of preeclampsia, macrosomia, cesarean section related to GDM, fetal complications were not significant between two groups. There was a significant difference between the two groups in terms rate of insulin therapy (p = 0.035), but there was no significant difference between the two groups in term of other pharmacological and non pharmacological treatment. The frequency of GDM in the first trimester was significantly more than the second trimester (p = 0.001). Conclusion: It can be concluded that early screening for GDM leads to more costs and discomfort. So, screening for each patient should be done individually in accordance with an accurate assessment of his pregnancy and risk factors for diabetes.