HN-02470279_Prevalence, Probable Causes andClinical Outcomes ofEnteral Tube Feeding Intolerance

Introduction: Enteral tube feeding intolerance (ETFI) is the most common complication of enteral nutrition (EN) and usually can lead to an insufficient nutritional goal, increased mortality and length of ICU stay. In this study, we aimed to determine the incidence and prevalence of ETFI to assess the influence of feed intolerance on nutrition and clinical outcomes.Methods: We conducted a cross-sectional study inintensive care units (ICU). Collected data included demographic characteristics, primary diagnosis, acute physiology and chronic health evaluation (APACHEІІ) Score and sequential organ failure assessment (SOFA) scores, duration of mechanical ventilation, and length of ICU stay. ETFI was determined as interruption of EN due to gastrointestinal reasons including large gastric residuals, abdominal distension, vomiting, diarrhea or subjective discomfort and was assessed by daily questionnaire for 7 days.Results: Data from 245 critically ill patients (122 males and 123 female) were analyzed. The highest incidence ofintolerance (91.8%) occurred in the second day and decreased in the following days. The lowest ETFI incidence occurred on the last day (38.8%). ETFI was associated with increased APACHE (p=0.04) and SOFA scores (p<0.001), and duration of mechanical ventilation (p<0.001) compared to tolerant groups. The most common cause ofintolerance in ICU patients, were gastric residual volume (GRV), large GRV, vomiting and distension, respectively.Conclusions: EFTI is frequently in ICU patients and almost occurs in two-thirds (66%) of critically ill patients receiving EN. EFTI is commonly defined based on GRV and is associated with worse nutrition status and clinical outcome.

کلیدواژه ها:

critical care ، enteral nutrition ، Intolerance ، intensive care ، mortality