Introducing bromoporphyrinato Zinc(II)as a best photosensitizer through the biologicalinvestigation for applying in photodynamic therapy

Porphine structure include four pyrrole units that connected by four methine bridges(–CH=) [1]. Metalloporphyrins can becoordinated to axial ligands which attached to metal. In this article a table has classified in five categories of metalloporphyrins with high photosensitizer effect. In the class (I) there are tetraphenylporphyrins (TPP) metal complexes with and withoutaxial ligands. Classes (II) and (III) are include metalloporphyrins with electron withdrawing and donating groups in para, ortho, and meta situations of phenyl and βsituations of macrocycle in TPP, respectively.classes (IV) and (V) are metalloporphyrins with aromatic functional groups in para situation of phenyl in TPP and meso situations of macrocycle, respectively. In this research, westudiedphotosensitizer effectand toxicity effectof metalloporphyrinsby PASS software. Investigation of photosensitizer effectof metalloporphyrins is important inbiology and medical. As an illustration, in photodynamic therapy (PDT) has been used compounds with high photosensitizer activity. Thereforit’svery essential for cancer treatment that has been evaluated percentage of mentioned activity [2]. The purpose of this article is identification a porphyrin complex with the most photosensitizer activity and the least toxicity. By investigationof the prepared table include 53 porphyrin complexes, was concluded that among 31 compounds with activity probability (Pa) above 90%,compounds number 30 and 31 {2-Bromoporphyrinato Zinc(II):[Zn-1BrP]and Zinc(II)-2,3-di(bromo)-12-formyl-5,10,15,20-tetraphenylporphyrin:[ZnTPP(CHO)Br2]}has 93.7% and 91.6%respectively without any toxicity.In comparison of compounds 30 and 31,[Zn-1BrP]introduceas the best photosensitizer for utilizing in PDT.