Investigation of biological activity and toxicity of the quenchers that applied for water soluble 5,10,15,20-tetrakis(4-carboxylphenyl)porphyrin (TCPP)

In recent decade porphyrins and metalloporphyrines have been used as chemosensors to sense many materials like metal, toxic and pollutant compounds. Detection of nitro aromatics as explosive compounds is important. One of the suitable method to detect these compounds is fluorescence spectroscopy [1, 2].In this work we investigate some biological activity and toxicity of a number of nitroaromatics by PASS software to choose which one has better antiprotozoal activity as seen in table below. Trinitro-fluoren-9-one [TN-9-one] has 67.2% for antiprotozoal activity which is the greatest value in the range of 41.2% to 67.2%. It has been studied in previous works by Sharma S. and et al. [3]. Also mutagenic and carcinogenic toxicities were compared among molecule sets. If we want to choose the best molecule with respect to T2 (embryotoxic) amounts there is no choice except [t-p-nitrostilbene]