Evaluation of Effective Factors in Antibacterial Performance in Layer-Pillared MOFs

Today, the problem of bacterial and pathogenic resistance to antibiotics is increasing and has become a major problem in societies, and many efforts are being made to deal with it [1].Metal organic frameworks(MOFs) are porous crystallinematerial that can be synthesis by self-assembly of metal ions and ligands and there are several methods to synthesize them [2,3]. Layer-pillared MOFswith formula [M (bdc) (dabco) 0.5] are made from two-dimensional paddlewheel cluster layers of M-terephthalatethat convert to three-dimensional structures with dabco [4].Due to the proper properties of MOFs, special attention has been paid to them in the field of antibacterial activity [5].Antibacterial properties of metal ions such as zinc and copper in various MOF have already been proven[6].In this work two layer-pillared MOFs were synthesized by solvothermal and sonochemical methods using copper ions and copper-zinc ions as connectors in their structuresand characterization methods were employed to determine their structures. Antibacterial activities of samples were evaluated by agar well diffusion method against two gram-positive and gram-negative bacteria. The results showed that the antibacterial activity depends on the size of the particles and the type of metal ion used in the MOFs structure.The MOF that had the smallest particle size and made of copper ions only, showed the most antibacterial activity.