THE EFFECTS OF GARLIC ON CONTROLLING CARDIOVASCULAR RISK FACTORS IN HEALTHY ADULTS

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 353

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شناسه ملی سند علمی:

INC15_333

تاریخ نمایه سازی: 30 دی 1397

چکیده مقاله:

Background and Aim: This study was designed to investigate whether garlic tablet is effective in prevention of cardiovascular disease (CVD) through controlling some CVD risk factors in healthy adults.Methods: The trial included 13 healthy adults in a randomized, placebo-controlled, cross-over design with 3-week treatment period. Participants received either garlic powder tablets twice daily or two placebo tablets/day for 3 weeks. Height, weight and blood pressure were measured and fasting blood samples were taken at baseline and after each 3 weeks treatment with garlic or placebo. Results: The mean age of participants was 37.66±1.98 years old. After 3 weeks, mean total cholesterol tended to have significant reduction in the garlic group (p= 0.04), and LDL cholesterol increased significantly in the placebo group (p= 0.04). A marker of systemic in ammation (plasma C-reactive protein), blood pressure, triglyceride and HDL cholesterol did not change signi cantly during the study.Conclusion: Three weeks of treatment with garlic powder tablet had some favorable effects on total and LDL cholesterol but did not exert anti-inflammatory or blood sugar-lowering effect in a healthy individuals. The findings of the present study lead us to speculate that in persons with normal lipid profile, garlic have little impact on these cardiovascular risk factors.

نویسندگان

Marjan Mahdavi-Roshan

Cardiovascular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht,Iran. ۲- Department of Community Medicine, School of Medicine, Guilan University of Medical Sciences,Rasht, Iran

Javad Nasrollahzadeh

Department of Clinical Nutrition & Dietetics, National Nutrition and Food Technology Research Institute,Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran