HESPERIDIN, A MAJOR FLAVONOID IN ORANGE JUICE, DOES NOT AFFECT LIPID PROFILE AND BLOOD PRESSURE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED CLINICAL TRIALS

Background and Aim: This study aimed to evaluate the efficacy of hesperidin supplementation on lipid profile and blood pressure with the use of a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: PubMed, Web of science, Scopus, and Google scholar as well as the reference lists of identified relevant RCTs were searched up to May 2018. The risk of bias in individual studies was assessed using Cochrane collaboration’ tool. Data were pooled by using the random-effects model and expressed as weighted mean differences (WMDs) with 95% confidence intervals (CIs). Statistical heterogeneity was assessed by the Cochran s Q test and I2 statistic. Results: Ten RCTs (n=577 participants) with 3 to 12 wk of duration were reviewed in this study. There was no significant difference between hesperidin and control groups regarding the changes in serum total cholesterol (WMD=-1.04 mg/dl; 95% CI: -5.65,3.57), LDL cholesterol (WMD=-1.96 mg/dl; 95% CI: -7.56,3.64), HDL cholesterol (WMD=0.16 mg/dl; 95% CI: -1.94,2.28), and triglyceride (WMD=0.69 mg/dl; 95% CI: -5.91,7.30), with no significant between-study heterogeneity. Hesperidin supplement also had no effect on both systolic (WMD=-0.85 mmHg; 95% CI: -3.07,1.36) and diastolic blood pressure (WMD=-0.48 mmHg; 95% CI: -2.39,1.42). Conclusion: We did not find any significant beneficial effect of hesperidin on blood pressure and lipids. Hesperidin supplementation is not recommended for improving cardiovascular risk factors.

کلیدواژه ها:

Hesperidin ، Citrus Flavonoid ، Lipid Profile ، Blood Pressure ، Meta-Analysis