EVALUATING OMEGA-3 SUPPLEMENTATION EFFECT ON SERUM LEVELS OF TOTAL OXIDANT STATUS (TOC), TOTAL ANTI-OXIDANT CAPACITY(TAC) AND LIPID PROFILE IN MALE PATIENTS WITH CARDIOVASCULAR DISORDERS

Background and Aim: Cardiovascular diseases are the major causes of death and disability in both developed and developing countries. Also EPA and DHA reduce oxidative stres. Oxidative stress is the major factor in the pathogenesis of endothelial dysfunction and many CVD risk factors. There is an inverse relationship between plasma antioxidant level and the prevalence of atherosclerosis in peripheral vessels. So, the aim of this study was to investigate the effects of omega-3 fatty acid supplementation on serum levels of total oxidant status, total antioxidant capacity in male patients with cardiovascular disorders.Methods: In this study was conducted as a double-blind clinical trial, 42 patients with cardiovascular diseases were randomly divided into 2 groups of placebo and omega-3 fatty acids receiver. Each patient was given omega-3 supplement or placebo at a dose of 4 grams per day for 2 months. Body composition and anthropometric indices was assessed before and after intervention. Also serum TAC , TOS and lipid profile were assessed at the beginning and at the end of study. Results: In the current study, no significant difference was observed in the body composition and anthropometric indices before and after intervention in both groups. A significant difference was seen in LDL level in both groups (p=0.012). Triglyceride level also decreased after the intervention in the omega-3 group (p=0.002). However no significant difference was seen in TOS and TAC levels during intervention in both groups and within each group.Conclusion: It was concluded that omega-3 fatty acids supplementation can not decrease the TAC and TOS serum level significantly.

کلیدواژه ها:

Total Oxidant Status(TOC) ، Total Anti-Oxidant Capacity(TAC) ، lipid profile ، Cardiovascular disorders ، omega-3