Diagnostic Value of NT-pro BNP Biomarker and Echocardiography in Cardiac Involvements in Beta-thalassemia Patients

سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 300

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شناسه ملی سند علمی:

JR_INJPM-5-11_012

تاریخ نمایه سازی: 20 مهر 1398

چکیده مقاله:

Background N-terminal pro–B-type natriuretic peptide (NT-proBNP) is a marker to evaluate the cardiac involvement in thalassemia. We aimed to evaluate conventional and tissue Doppler echocardiography findings and its relation to plasma NT-pro BNP, Ferritin and Iron levels in beta-thalassemia patients. Materials and Methods This study performed on 164 participants equal of major beta- thalassemia patients (n=82), and controls (82 healthy children with normal cardiovascular status). The patients collected from outpatients after applied exclusion criteria. Blood samples were taken from participants in fasting to measure NT- pro BNP, Ferritin and Iron serum. Participants were under echocardiography by Pediatric cardiologist. The level of error considered as 0.05 for data analysis by SPSS version 20.0. Results  NT- pro BNP, Iron, Ferritin, left S , left A , right A , EF, FS, left and right A/A ; right and left MPI were significantly different in patients group (P<0.05). FS and EF were higher in younger’s and left and right MPI were lower. In higher level of NT-pro BNP right S had converse trends compared with the Iron, its level was higher in patients > 10 years, and FS had different values significantly in lower levels. In lower level of left E/E resulted that FS was significantly higher in the age group < 10 years. Right peak E velocity was significantly higher in younger’s in higher level of left E/E . Right E/E was significantly higher in elders in lower level of left E/E (P<0.05). Conclusion The study confirmed that NT-pro BNP increases in thalassemia and association with age and LV diastolic dysfunction. NT-pro BNP with E/E and S were shown diastolic and systolic dysfunction in thalassemia. Therefore, an increased level of ferritin and NT-pro BNP can be used as a marker for the intensification of iron chelation therapy, which reverses iron-induced cardiomyopathy.

نویسندگان

Noor Mohammad Noori

Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

Alireza Teimouri

Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

Maryam Nakhaey Moghaddam

Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.