Aloysia citrodora extract decreased hormonal signs of post-traumatic stress disorder (PTSD) induced by electric shock in rats

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 419

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شناسه ملی سند علمی:

NSCMED08_127

تاریخ نمایه سازی: 15 دی 1398

چکیده مقاله:

Background and Aim : Aloysia citrodora is a medicinal plant which has been has various used in traditional medicine. Traditionally, this medicinal plant has sedative and anti-anxiety, anti-stress and memory improvement effects and has been used to cure different diseases such as migraine, sleep disorders, and etc. The post-traumatic stress disorder (PTSD) is among the most important mental disorders of our century which causes great stress and several complications for the afflicted person. Nowadays, the definition of PTSD comprises not only those affected by the accident, but also those who have witnessed it. Therefore, in the current study, we aimed to investigate the effects of Aloysia citrodora extract on hormonal signs of PTSD caused by electric foot shock.Methods : Male Wistar rats (250-300 g weight) were used in this study. The animals randomly received electric foot shock (0.1 mA) for 100 seconds over a period of 10 days. After returned to cages to repose for 21 days, the animals were put back into the stress box but received no stress. The animals received different doses of Aloysia citrodora extract (5, 10, 20 mg/kg) intraperitoneally 10 min before placing into the stress box (n = 7-9 rats/group). Control group received saline (1 mg/kg). Plasma corticosterone levels were assessed by ELISA kit in control and treated animals.Results : One-way ANOVA showed that stress elevated plasma corticosterone level (129 nmol/L) concentration in the control animals. Intraperitoneal administration of the Aloysia citrodora extract reduced plasma corticosterone level (81 nmol/Conclusion : These findings indicate that Aloysia citrodora extract can reduce hormonal signs of PTSD and can use as an agency for moderation of PTSD signs.

کلیدواژه ها:

Post-traumatic stress disorder (PTSD) ، Aloysia citrodora extract ، Corticosterone

نویسندگان

Zahra Bakhshandeh

Shahid Ahmadi Roushan Student Research Center, Baharestan ۱ education office, Baharesta, Tehran, Iran

Fatemeh Jabbari

Shahid Ahmadi Roushan Student Research Center, Baharestan ۱ education office, Baharesta, Tehran, Iran