Background and Aim :
Epilepsy is a chronic neurological disorder characterized by frequent seizures. One of the important types of epilepsy from the clinical point of view is temporal lobe epilepsy, which is the most common topical epilepsy in adults that is resistant to commonly used treatments. Over the past two decades, there have been many advances in drug therapies for epilepsy and complications, but about one third of patients still have not responded to common medications. The aim of this study was to determine the role of 5-HT3 receptors Blockade in the entorhinal cortex on the Discrimination index in Elevated Plus maze in the electerical amygdala kindled rats.Methods : Male Wistar rats (weighing 270–350 g) were used in this study. Animals were assigned to seven groups as control, sham, kindled, kindled + vehicle, kindled + Ramo. 1μg, kindled + Ramo. 10μg, kindled + Ramo. 100μg. In kindled + vehicle group, animals were injected with ramosetron vehicle and then received the kindling stimulations. In kindled + Ramo. 1 μg group, animals were injected with ramosetron 1μg / 0.5 μl (ICV) and then received the kindling stimulations 24 h after applying the vehicle injection. In kindled + Ramo. 10 μg group, animals were injected with ramosetron 10 μg / 0.5 μl (ICV) and then received the kindling stimulations 24 h after applying the vehicle injection. In kindled + Ramo. 100 μg group, animals were injected with ramosetron 100μg / 0.5 μl (ICV) and then received the kindling stimulations 24 h after applying the vehicle injection. At the end of each step, the Elevated Plus maze Behavioral Test was performed.Results : Injection of high and moderate doses of 5-HT3 receptor antagonist following electerical amygdala kindled, reduced the time elapsed in the open arms and injected a moderate dose of 5-HT3 receptor antagonist decreased the number of entries into the open arms.Conclusion : It was shown that the 5-HT3 receptor antagonist increases animal stress and anxiety.Previous studies have shown that the stressful function of 5-HT3 antagonists may be related to the cholecystokinin peptide (CCK). Increased central function of CCK in human and animal models leads to stress, anxiety, fear and panic, and thus the ability of the 5-HT3 receptor to increase CCK release may be related to its behavioral change. The results of our studies confirm the results of our experiments. Another study also found that kindling encourages animals to enter the arm more often. A process that does not matter and does not matter but is consistent with other symptoms of increased stressful activity. This study is consistent with our experiments.