Investigation of preparation of chitosan / polyethylene oxide polymer nanofibers and mupirocin additive by electrospun technique for use in surface wound coating.

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 309

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شناسه ملی سند علمی:

WTRMED06_172

تاریخ نمایه سازی: 5 بهمن 1398

چکیده مقاله:

Introduction: The different methods have been innovated for dressing of the sore and utilized, in this study, we followed to find and promote a new method for dressing of superficial sores. In previous and current methods, there are several problems such as non-biocompatible, non-biodegradable. The necessity for replacing of the sore cloth led to pain and refreshed the sore, infection and scar.Material and method: In the first studies, the dressing of the kind of the co-polymer of Chitosan/PEO and adding of the Mupirocin antibiotic was considered which obtained solution through Electro spinning apparatus scatter in the nanofibers form on the aimed surface, both of these polymers were biocompatible and biodegradable and also have an effective role in repair and improvement of the sore, it has demonstrated that Chitosan has antibacterial role against some infectious agents, like Pseudomonas aeroginosa and E.Coli. Antibiotic of Mupirocin is effective against Staphylococcus aureus and Streptococcus pyogenesis.Findings: The results of our studies and experiments indicated that the best form of the nanofibers was produces by the ratio 90/10 of Chitosan/PEO, but in the experiments, after adding the Mupirocin to above-mentioned solution, we can’t have any nanofibers containing of this antibiotic permanently, means after deposit of the fibers on the surface, fibers attached to each other and sit down on the surface in the form of the layer.Conclusion: In bacteriological studies, we got results similar to the scientific resources, in this form that Chitosan 2%, polymeric solution 90/10 of Chitosan/PEO and the solution containing of Mupirocin even with 0.5% have bacteriostatic and bactericidal effects against of Staphylococcus aureus (ATCC6538).In animal studies, we observed the effect of these solutions and produced nanofibers in repair of the burn sore on rat, certainly this subject needs to more studies and experiments.

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نویسندگان

Asgar Emamgholi

Ph.D, student of tissue engineering, Iran medical science university, Tehran, Iran