Coexistence of papillary thyroid carcinoma and chromophobe renal cell carcinoma: A case report

Background: The coexistence of two separate malignant tumors occurring within the twoseparate organ are extremely rare. Although very rare, collision tumors have been describedboth in the thyroid as well as in other organs. The thyroid gland has been shown to harbordifferent types of malignancies of thyroid origin. Metastases to the thyroid are extremely rare.Case presentation: A woman aged 55 years presented with a several months history ofpalpable mass of thyroid. The computed tomography scan of the abdominal space showed amass in the upper pole of left kidney. Given fine needle aspiration findings of thyroid masssuggestive of papillary thyroid carcinoma .He underwent total thyroidectomy and leftnephrectomy. Histologic evaluation of multiple sections from both lobes of the thyroid showsa papillary neoplasm. The neoplastic papillae are lined by columnar cells with ovoid opticallyclear nuclei, with occasional intranuclear pseudoinclusions.The nephrectomy specimen showed a 8x5x3 cm tumor at the upper pole with a homogenous,solid light brown cut surface. The tumor was limited to his kidney. The sections stained byhematoxylin and eosin showed sheets of polygonal cells with abundant granular eosinophiliccytoplasm with oval nuclei, convoluted nuclear membranes, and perinuclear cytoplasmicvacuolization. Histology revealed Chromophobe renal cell carcinoma.Conclusion: The coexistence of two separate malignant tumors occurring within the twoseparate organ are extremely rare. Papillary thyroid carcinoma (PTC) is, by far, the mostcommon type of thyroid malignancy, with an incidence that is considerably higher thanthat of follicular tumors in iodine-rich areas. Chromophobe renal cell carcinoma is a distinctsubtype of renal cell carcinoma, possibly originating from the intercalated cells of thecollecting tubules. It comprises approximately 5% of all renal tumors.

کلیدواژه ها:

Chromophobe renal cell carcinoma ، kidney ، papillary carcinoma ، thyroid