The relation between the vascular formation and cellular proliferation with gender and age in oral squamous cell carcinoma (OSCC)

Background:Cell proliferation and new blood vessels formation are critical factors in metastasis and prognosis of malignant tumors.The relation between metastasis and prognosis with gender and age is not elucidated. Aim: The aim was to study the relation between the vascular formation and cellular proliferation with gender and age in Oral Squamous Cell Carcinoma(OSCC). Materials and Methods:The study was retrospective.24 paraffin-embedded samples of well differentiated OSCC was detected immunohistochemically for Vascular Endothelial Growth Factor (VEGF) and Ki67 expression.The Labelling Index(LI:positive epithelial cells/1000 epithelial cells) of VEGF and Ki67 positive cells were obtained.The correlation between VEGF and Ki67 expression with gender and age was determined . The linear regression and spearman tests were used for statistical analyzing. Results:The correlation between VEGF expression with gender and age was not significant(p=0.67 and p=0.88,respectively).The correlation between Ki67 expression with gender and age was not significant (p=0.43 and p=0.88,respectively). Conclusion:Blood vessels formation and cell proliferation are not related to gender and age in OSCC.

کلیدواژه ها:

Cellular proliferation ، Vascular Endothelial Growth Factor ، Oral squamous cell carcinoma