Investigating type of tissue changes and its associated factors in bodies were sent to Tehran legal medicine organization in death from poisoning tramadol (2008-2013)

Background: One of the most common causes of death in the world is caused by poisoning. Recently the abuse of prescription drugs has increased and Tramadol is also no exception. In order to evaluate the histological changes and its associated factor resulting in tramadol toxicity, tissue changes due to age, sex, history of addiction, the involved member, the occurrence of death from tramadol was assessed. Methods: The present study was a Cross-sectional study on all bodies in biological fluids positive tramadol or had a clinical history of tramadol and has been sent to Tehran Legal Medicine Organization during the last five years (2008-2013) . Finally the data was analyzed through SPSS software. Findings: In this study, 49 corpses were examined, according to sex was 39 men (79/5%) and 10 women (20/5%). Most of the corpses were aged 25-34 years (40.8%) with a mean of 27 years. Among all examined corpses 41subjects (83/6%) have been dead without any history of Tramadol use and none of them had a history of using irritants in their file. Among the symptoms before the death with cardiopulmonary arrest (67/3%) was the most obvious sign is seen on the deceased and gastrointestinal symptoms did not observed. Pathological changes in the macroscopic and microscopic examination of examined organs; the most common finding was related to the liver and brain sample so that the brain edema in 25 subjects (51%) and degeneration of hepatocytes (32.7%) samples were observed. Changes in both brain and liver tissue samples showed a significant relationship (p-value <0.05), with the recent history of taking tramadol.Conclusion: The death rates among tramadol poisoning that referred to dissection and were examined was among young men. The highest rate of positive samples of gastric contents in the samples deceased, the best sample that will help us would be the stomach contents. And the best sample to study the pathological changes among corpses poisoned with tramadol would be the liver and brain sample that had most changes in our investigations.

کلیدواژه ها:

poisoning ، tramadol ، tissue changes ، Toxicology