The prevalence of high risk human papillomavirus in ovarian endometriosis

In this study, we aimed to determine the prevalence of human papillomavirus (HPV) in ovarian endometriosis and ovarian tissue from women without endometriosis. Understanding the pathogenesis of the disease could help us design preventative strategies as well as novel and appropriate treatment approaches in this regard. In this cross-sectional study,formalin fixed and paraffin embedded tissues of 50 ovarian endometriosis and 49 ovaries without endometriosis were evaluated for the presence of high risk HPV using polymerase chain reaction (PCR) technique. Prevalence of HPV infection and other related characteristics of studied population were compared.High riskHPV infection was detected in 42(84%) and 27(55.1%) of samples with and without endometriosis, respectively (P=0.02, X2= 8.32). Mean of age and parity was not significantly different in subjects with and without HPV infection in both studied groups (P=0.7 and P=0.06 for age in case and control groups, respectively and P=0.32 and P=0.09 for parity in case and control groups, respectively).The results of our study indicated a higher rate of high risk HPV infection among patients with endometriosis. The findings could provide us baseline information for future studies regarding the pathogenesis of endometriosis and the role of viral infection and their impact on future cancer development in this group of patients.

کلیدواژه ها:

Endometriosis ، High risk ، Human papillomavirus