The study of antibiotic resistance pattern among children infected by enteric Escherichia coli , a retrospective survey, Iran

Introduction and objectives Resistance to antibiotics is a main health problem in last decades and causing a lot of problems for infections treatment. Especially, drug administration without antibiogram tests enhances the intensity of the problem. The aims were assessing prevalence of resistance to antimicrobial agents at microbiology lab, and correlation with demographic variables like age, gender, socio- economic factors. Material and methods In a cross sectional study in March 2014 to march 2015 , we examined 580 stool specimen of 5 to 14 years old children. The resistance patterns were compared with age and gender . Standard microbiological methods were used to culture and antibiogram tests. All information were analyzed by SPSS and chi square softwares. Results: The findings revealed that in 32 positive cases , 20(62.5%)Escherichia coli, 6(18.75%)Proteus mirabilis and 6(18.75%)Shigella sonei were the most common bacteria who isolated. The rate of resistantancy for E.coli were, ciprofloxacin (10%),tetracycline (60%), ampicillin (70%), sulfamethoxazole/trimethoprim (40%) and amoxicillin/clavulanic acid (30%). There was no significant correlation between resistance and age or gender (P> 0.05 %). But the most of resistance cases were seen in children with low educated mothers (P<0.05). Conclusion: Findings demonstrated the remarkable resistance rate for antimicrobial agents. Results were similar to the other studies but for E coli, there was a big resistance to tetracycline and ampicillin. We suggest using antibiotics after antibiogram test and Educational plans for physicians and patients.

کلیدواژه ها:

antibiotic ، resistance ، e coli