Expression of OCT4, SOX2 and NANOG in oral squamous cell carcinoma versus the non-tumoral adjacent tissue

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 396

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شناسه ملی سند علمی:

ACPLMED19_027

تاریخ نمایه سازی: 20 آبان 1397

چکیده مقاله:

Background and Objectives: Oral squamous cell carcinoma (OSCC) accounts for over 90% of oral neoplasms. Finding the markers for predicting prognosis of OSCC is of high value. The OCT4, SOX2, and NANOG are the core transcription factors related to proliferation and differentiation of stem cells and shown to be essential for progression of various malignancies. However, the predictive value of such stemness markers for OSCC and their implication in the development of this cancer is still controversial. In this study, we aimed to evaluate the expression of OCT4, SOX2, and NANOG in OSCC versus the adjacent non-tumoral tissue. Materials and Methods: 60 frozen tumoral and non-tumoral adjacent tissues from 30 patients with OSCC were examined for the expressions of OCT4, SOX2, and NANOG using quantitative reverse transcription polymerase chain reaction (qRTPCR). Clinical and pathological data of patients (including tumor stage, lymph node metastasis and tumor grade) were also recorded. Results: Expression of SOX2 was significantly higher in the adjacent non-tumoral tissue compared to tumoral tissue (P=0.04). No statistically significant difference was found between expression of OCT4 (P=0.50) and NANOG (P=0.68) in tumoral and non-tumoral tissues. No significant association was present between the expression of OCT4, SOX2, and NANOG with clinical or pathological data (P> 0.05). However, expression of OCT4, SOX2 and NANOG genes was slightly, but not significantly, higher in patients without lymph node metastasis. Conclusion: Based on the present data, decreased expression of SOX2 is correlated with initiation of carcinogenesis in the oral cavity and development of OSCC.

نویسندگان

neda kardouni

Department of oral and maxillofacila pathology,dentistry faculty, Tehran university of medical sciences, Tehran, Iran