The study for diagnostic value of B-Catenin immunohistochemistry marker in distinction of aggressive and non aggressive Basal cell carcinoma

Background: Basal cell carcinoma (BCC) is a common skin cancer arising from the basal layer of epidermis and its appendages. they are locally invasive, aggressive, and destructive of skin and the surrounding structures. β-Catenin is a multifunctional protein located to the intracellular side of the cytoplasmic membrane coded by the CTNNB1 gene, which maps to chromosome 3p22.1. It has a critical role in cell-to-cell adhesion by linking cadherins to the actin cytoskeleton and has a central role in transcriptional regulation in the Wnt signalling pathway.we evaluated the for diagnostic value of Beta catenin immunohistochemistry marker in distinction of aggressive and non aggressive Basal cell carcinoma. Materials and Methods: This cross sectional and descriptive-analytical study was done on archived formalin fixed, paraffin embedded tissue blocks in pathology library of Al-Zahra hospital in Isfahan city. We used immunochemistry to determinate role of β-Catenin in aggressiveness in BCC with higher rate of relapseResult: A total of 76 samples were evaluated in two groups(aggressive &none aggressive). mean percentage of cytoplasmic β-Catenin staining in aggressive group were significant more than other group(P ث‚ 0.001 , sensitivity: 86.8%,specificity: 81.6%,PPV:81.5% and NPV:86.1%)and mean percentage of membranous β-Catenin staining in non aggressive group were significant more than aggressive group(p ث‚ 0.001 ). intensity of membranous staining in both groups significant less than normal epithelium(p .(ث‚ 0.001 Conclusion : Cytoplasmic β-Catenin stainig in aggressive BCC more significant than non aggressive subtypes , so indicate that use of β-Catenin IHC marker maybehelpful in diagnosis of aggressive BCC.

کلیدواژه ها:

B-Catenin ، BCC ، Aggressiveness ، sensitivity ، specificity