The role of microRNAs in endometriotic lesion development

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 361

نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

ACPLMED19_098

تاریخ نمایه سازی: 20 آبان 1397

چکیده مقاله:

Background Endometriosis, a common estrogen-dependent reproductive disorder, is characterized by the presence of endometrial tissues outside the uterine cavity. AThere is increasing evidence that epigenetic mechanisms such as microRNAs (miRNAs) play important roles in the pathogenesis of this disease. details, Hypoxicinjury, Inflammation, Angiogenesis, Cell proliferation, Transforming growth factorb- regulated pathways are essential systems in the pathophysiology of this disease.Method: This study is a review article, after searching in databases such as Scopus, Science Direct, PubMed, google scholar with keywords as microRNA; biomarker; endometriosis, 20 articles published full text between 2005 and 2016. Result: Hypoxia-induced factor-α (HIF-1α) activity appears to be Hypoxia-induced factor-α is inhibited by miR-20a which is down regulated in ectopic endometrial tissues, potentially contributing to HIF-1α’s up-regulation. IL-1β, TNF-α, NFκB, HIF-1α and COX-2 are all found at high levels in endometriotic lesions, and inhibition of TNF-α and COX-2 has been shown to suppress endometriosis-like lesion development. Reduced expression of miR-199a and miR-16 in endometriosis is likely to enhance COX-2 protein production, resulting in enhanced prostaglandin production, neo-angiogenesis and activation of the aromatase/COX-2 feed forward loop, leading to enhanced local estrogen levels. In endometriosis, increased expression of VEGF-A may therefore result from low levels of miR-15b and miR- 16. Elevated levels of miR-126 in endometriosis are also likely to enhance VEGF activity by relieving the negative inhibitory effect of downstream supressors of the VEGF-A pathway. Vascular endothelial cell migration may also be promoted by the upregulation of MiR-143 and miR-145 which enhance the contraction of vascularsmooth muscle cells in vitro. Conclusion: There is now good evidence of a role for miRNAs in endometriotic disease. We are just beginning to understand the full impact of miRNA technology. it is possible that these small non-coding RNAs may become an important branch of our medical armamentarium for diseases such as endometriosis.

کلیدواژه ها:

نویسندگان

Sakine Arabfiroozjaei

Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

mehrdad nurozinia

Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran