The effect of chronic administration of Apigenin flavonoid on contractile and relaxation response of thoracic aorta among diabetic rats

Background and Aim: Diabetes mellitus is accompanied with higher incidence of cardiovascular disorders. There is some evidence on antidiabetic and vasorelaxant potential of apigenin. Thus, the effect of its chronic administration on contractile and relaxation response of thoracic aorta from diabetic rats was investigated.Materials and Methods: In this experimental study, male Wistar rats were divided into 4 groups, i.e. control, apigenin -treated control (10 mg/kg), diabetic, and apigenin -treated diabetic groups (10 mg/kg). apigenin was administered (i.p.) ten days after streptozotocin injection for 3 weeks. At the end of study, contractile reactivity of thoracic aortic rings to KCl and phenylephrine and relaxation response to acetylcholine was determined using isolated tissue setup. Results: Apigenin -treated diabetic group showed a non-significantly lower maximum contraction to KCl and a significantly lower maximum contraction to phenylephrine (p<0.05) as compared to diabetic group. Meanwhile, maximum relaxation response of rings to acetylcholine was significantly higher in apigenin -treated diabetic group as compared to diabetics (p<0.01). In addition, there was also a lower contractile response to phenylephrine in apigenin -treaded control and a higher relaxation response for apigenin -treated control group versus controls (p<0.05). Conclusion: Administration of apigenin could decrease contractile response to phenylephrine and enhance relaxation response in aortic tissue of diabetic rat and this may be beneficial in prevention of long-term vascular complications of diabetes.

کلیدواژه ها:

Apigenin ، Diabetes mellitus ، Aorta ، Contraction response ، Relaxation response