Heritability of Corneal Curvature and Pentacam Topometric Indices: A Population Based Study
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 412
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شناسه ملی سند علمی:
ACSOMED28_127
تاریخ نمایه سازی: 1 دی 1397
چکیده مقاله:
Purpose: to investigate familial aggregation of anterior and posterior corneal curvature, corneal astigmatism and some corneal topometric indices using Pentacam.Methods: Of the 3851eligible individuals who resided in the selected areas, 2779 people had the conditions for analysis. However, analysis was limited to families whose Pentacam measures were available for at least 2 family members, resulting in 1383 individuals in 382 families. All selected subjects had a set of examinations including refraction, uncorrected and corrected visual acuity, slit lamp Biomicroscopy and Pentacam imaging. Heritability estimation was used to calculate familial aggregation. Results: The results of our study showed fairly high corneal curvature heritability. The heritability of K2 and K1 in the anterior surface was 58.60% and 55.82%, respectively. The heritability of posterior corneal curvature was slightly higher than that of anterior corneal curvature. The heritability of K2 and K1 in the posterior surface was 63.42% and 59.67%, respectively. In investigating the quantitative topographic indices of the cornea, index of surface variance (ISV), Central Keratoconus Index (CKI) and index of vertical asymmetry (IVA) had the highest levels of heritability (81.2%, 74.99% and 66.46%, respectively) while Keratometric power deviation (KPD) and Index of height asymmetry (IHA) had the lowest heritability levels (7.48% and 18.31% respectively). Conclusion: the familial aggregation and relatively high heritability of corneal curvatures and some keratoconus related indices such as ISV and IVA confirm a high correlation between these phenotypes and genetic factors and warrant further investigation of the genetic mechanisms in keratoconus
نویسندگان
Samira Heydarian
Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran
Hassan Hashemi
Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran
Frida Jabbari-Azad
Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran
Mojgan Pakbin
Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran