Retinal and optic disc micro vascular changes after acute intraocular pressure elevation in healthy and diabetic patients measured by optical coherence tomography angiography
محل انتشار: بیست و نهمین کنگره سالیانه انجمن چشم پزشکی ایران
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 417
نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
ACSOMED29_046
تاریخ نمایه سازی: 30 آذر 1398
چکیده مقاله:
Purpose: : To assess the microvascular change of the optic nerve head and macula after acute rise of intraocular pressure (IOP) in normal and diabetic eyes. Methods: In this prospective, interventional, comparative study, ten normal and sixteen diabetic eyes without diabetic retinopathy (NDR) or with mild non-proliferative diabetic retinopathy (NPDR) were enrolled. IOP rise induced by a suction vacuum attached to the sclera. IOP was measured and optical coherence tomography angiographic (OCTA) images were obtained from the optic disc and macula, before and after IOP rise. The repeatability of the device in the vessel density measurements was calculated by analyzing the two consecutive imaging-derived data of the subjects before the intervention. Results: The change in IOP after activation of the suction was significant in all three groups (all P < 0.05). There was no significant difference in the amount of IOP change between the three groups (all P > 0.05). The changes in the vessel density in the macular deep and superficial capillary plexus was statistically significant in whole image and parafoveal area in normal subjects (all P < 0.05). Also, the change in the vessel density was significant in the inside disc measurements in NPDR. Other microvascular changes were not statistically significant. All microvascular changes in all three groups were less than the measurement repeatability of the OCTA device. Conclusion: Acute rise of IOP may induce different levels of microvascular changes in healthy and diabetic eyes.The results of this study may shed a light on the autoregulation mechanisms of the microvascular networks. Financial Disclosure: No
نویسندگان
Maryam Ashraf Khorasani
Eye Research Center, Rassoul Akram Hospital, Iran University of the Medical Sciences, Tehran, Iran
Pasha Anvari,
Eye Research Center, Rassoul Akram Hospital, Iran University of the Medical Sciences, Tehran, Iran
Abbas Habibi,
Eye Research Center, Rassoul Akram Hospital, Iran University of the Medical Sciences, Tehran, Iran
Sharyar Ghasemizadeh,
Eye Research Center, Rassoul Akram Hospital, Iran University of the Medical Sciences, Tehran, Iran
Khalil Ghasemi Falavarjani
Eye Research Center, Rassoul Akram Hospital, Iran University of the Medical Sciences, Tehran, Iran