Evaluation of olfactory threshold changes in patients with polyps before and after Endoscopic Surgery: a comparative study in Dr Kermanshahi Hospital during 2016-17

Background and Objective: Polyposis is one of the most common benign nasal masses. There are few studies about olfactory threshold changes after the polyps’ removal surgery (Polypectomy). Our objective was to compare the olfactory threshold changes in polyposis patients before and 6 months after the polypectomy. Materials and Methods: The comparative study was done on 53 patients using non probable convenience sampling method whom candidate for Polypectomy before and 6 months after the operation referred to the Dr Kermanshahi Hospital, Kermanshah, Iran during 2016-17. The olfactory threshold was determined by olfactory test using phenyl butyl alcohol in propylene glycol and the lowest propylene glycol detection used as olfactory threshold. Briefly, 9 serial diluted of phenyl butyl alcohol in propylene glycol samples (6.3-63%x10-6) and a pure phenyl butyl alcohol (control) were used in this study. In each tube the odor detected, the tube number recorded as olfactory threshold. Exclusion criteria was being the history of radiotherapy or chemotherapy, renal or hepatic disorders and diabetes mellitus. Also variables of age, sex, Lund-Mackay score (LMK) were gathered. All patients signed the agreement form and the research project has received the confirmation of the Kermanshah University of Medical Sciences Ethics Committee. Data collected and analyzed using SPSS Software version 24 (Chicago, IL, USA). Quantitative data were expressed as mean (±SD) and Qualitative data reported as Percentage. K-S test was used to assess the normality of study data. Means were compared using Paired T test and Wilcoxon test and level of significance was considered <0.05. Findings: The mean age was 36.72± 12.48 years old in the range of 17-80. Also 35 (66%) patients were male. The most frequency of olfactory threshold score, before and after the surgery, were 5(32.1%), and 7(45.3%) respectively. The gender in olfactory threshold test, before and after the operation, wasn’t significant (P> 0.05). However, there was significant difference in sex before and after the surgery based on LMK score (P=0.02). Significant difference detected in LMK score before (21.32±0.95) and after (0±0.00) the polypectomy (P=0.0001). Also the significant difference based on age were detected in LMK score and olfactory threshold before and after polypectomy (P=0.0001) Conclusion: These results suggested olfactory threshold (based on LMK score or olfactory test using phenyl butyl alcohol) improves after polypectomy. Taking into the account, age is an important and significant factor in this study. However, further longitudinal studies with bigger sample size is suggested to be done.

کلیدواژه ها:

Polypectomy ، Olfactory threshold ، Lund-Mackay Score (LMK) ، Propylene Glycol ، Phenyl Butyl Alcohol ، Polyps’ Removal Surgery