The Impact of the Helicobacter Pylori Treatment on the Quality of Life in the Patients with Chronic Idiopathic Urticaria

Background and Objective: Chronic Urticaria (CU) is one of the most common skin diseases with prevalence ranging between 15 and 25%. This disease takes more than 6 weeks and is often associated with angioedema. In many cases, the cause remains unknown and seems to be an idiopathic disease and may have a profound influence on patients’ quality of life. Drugs, food, viruses, alimentary conservative substance or inhalant substances often seem to be involved in determining CIU skin flare. In the majority of cases, there is no identifiable underlying etiology despite extensive evaluation but if the etiology of the disease is diagnosed, it can be cured. Despite a general agreement that bacteria infection and parasitic infestations can be involved in the pathogenesis of CIU, proven evidence of these relationships is lacking. The aim of this study is to assess the efficacy of Helicobacter pylori infection eradication in the improvement of the quality of life in patients with CIU. Method and materials: In this clinical trial study, 60 CIU patients (31 females and 31 males, range 20-70 years)were enrolled. The patients suffering from chronic urticaria were randomly divided into two groups: cases the patients infected with Helicobacter pylori received Omeprazole, Metronidazole, Clarithromycin (OMC)for 2 weeks and controls (placebo). The patients’ quality of life was compared using the Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL)before the treatment and one month after the treatment. The data were analyzed using SPSS 22. Findings: There was no significant difference between the two groups receiving OMC or placebo treatments regarding the quality of life before the treatment (P> 0.05). However, one month after the treatment a significant difference was observed (P<0.05). Conclusion: The results showed that the prescription of OMC was not effective in improving the quality of life of the patients suffering from chronic urticaria.

کلیدواژه ها:

Chronic Urticaria Idiopathic (CIU) ، Helicobacter Pylori Infection ، Quality of Life ، CU-Q2oL