The association of laboratory and clinical markers with disease activity score in rheumatoid arthritis
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 358
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شناسه ملی سند علمی:
AMSMED20_309
تاریخ نمایه سازی: 22 مهر 1398
چکیده مقاله:
Background: Disease Activity Score (DAS-28) is a clinical parameter of RA progression according to joint tenderness and swelling. It was reported that other parameters such as neopterin, rheumatoid factors (RF), and cyclic citrullinated protein antibody (Anti- CCP) could be involved in jointed destruction. This study aims to evaluate if these parameters have an association with disease activity of RA. Methods: Peripheral blood samples were collected from 47 patients and 44 healthy subjects. Then plasma levels of neopterin and Anti-CCP have been evaluated using ELISA method. Also, RF-positive patients were detected b latex agglutination test, and ESR levels were obtained from the patient s records. Results: The amount of neopterin, Anti-CCP and RF were significantly higher RA patients in comparison with healthy subjects (P=0.038), (P<0.001), and (P< 0.001), respectively. Also, the significant correlation between RF and DAS-28 (P< 0.001) has been shown in our study. The sensitivity and specificity of anti-CCP and RF were (89.1%, 86.95%) and (91.3%, 91.1%) for the diagnosis of RA, respectively. Conclusions: No correlation existed between the serum levels of neopterin and DAS-28 but RF levels could direct RA disease progression
کلیدواژه ها:
نویسندگان
Nasrin Iranshahi
Department of Immunology, school of medicine, Kermanshah university of medical sciences, Kermanshah,Iran
Parisa Zafari
Department of Immunology, school of medicine, Mazandaran university of medical sciences, Sari, Iran
Mahdi Taghadosi
Assistant professor in Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran