The effects of soy methanolic extract on serum interleukin-6 level and ovary tissue modification in polycystic ovary syndrome model

Polycystic ovary syndrome (PCOs) is the most common reason for infertility due to lack of ovulation among women in reproduction age that involves 10-15 percent of women. According to Rotterdam criteria, about 15.2 % of Iranian women suffer PCOs. Studies suggest that inflammation could be a concern in the pathobiology of this incident disorder. Now, to care the positive aspects of soy phytoestrogens effect on increasing the anti-oxidant and anti-inflammatory in the body and furthermore high incidence, lack of a definite cure for PCOs and side effects of existing cure methods, reveal the purpose of present investigation. In this study the syndrome induced by a single intramuscular injection of 40 mg/kg of Estradiol Valerate to 32 female Wistar rat (170-180 gr) in the estrus phase. Control group received no injection. After 60 days the animals divided to control, PCOs and PCOs treated with soy extract (50 and 100 mg/kg) groups. After 21 days of oral treatment of soy extract, the ovaries of all groups histologically studied and Serum interleukin 6 levels were detected by the ELISA kit. There was a signification polycystic improvement in ovaries treated with high concentration of soy extract in comparison with PCOs group and also granulosa layer increase, the thickness of the theca layer decrease, reduction of cystic follicular number and corpus luteum increase and IL-6 level decrease were found. Soy extract could decrease PCOS histological signs by decreasing the serum levels of inflammatory cytokines that lead to ovulation rate reduction, and have reparation effects on ovary tissue. It is possible that this ability is because of soy extract antioxidant and anti-inflammatory effects that motivate reduction of cysts number and natural development of follicles.

کلیدواژه ها:

Soy extract ، Polycystic ovary ، Infertility ، Inflammation