Study of the protective effects of Gordonia bronchialisin heart injury of diabetic rats

The present study was conducted to evaluate the protective effects of Gordonia bronchialis (Gb), as heat-killed Actinomycetales,on the biochemical and histological changes in Wistar rat after experimental diabetes mellitus induced by intraperitoneal injection of 55 mg/kg streptozotocin (STZ). The experiment was performed by oral administration of Gb at two doses of 105 (low dose) and 107 (high dose) mg/kg body weight in ten male rats (in each group) continuously for 14 days. The third group received normal saline as a diabetic control group and the last group mentioned as a negative control (no diabetic, no treatment). The effects of this bacteria were determined on 21st days post study by histopathological examination of the heart with a common method. Moreover, biochemical parameters including CK (Creatinine Kinase), serum glucose level, cholesterol, and triglyceride were measured on the blood samples. In the present results, significant differences were observed in the pathological lesions such as degenerative changes in myocardial cells, focal hemorrhage, capillary congestion and edema which were less severe in both treatment groups compared to the diabetic group. Additionally, CK, serum glucose level, cholesterol, and triglyceride measurement showed significant differences in both treatment groups compared to diabetic rats. On the basis of the current findings, it seems that oral administration of Gb can improve heart damage induced by STZ-induced diabetes mellitus in Wistar rat. In conclusion, the present results suggest that the heat-killed Gb can have beneficial effects on diabetes mellitus complications.

کلیدواژه ها:

Gordonia bronchialis ، Diabetes mellitus ، Pathological lesions ، Biochemical change